The Facility provides pilot-scale and bench-top-scale fermentation equipment Training of graduate students or technicians in the operation of batch and continuous fermentation fermentors, and microbial culture maintenance and preservation is available. The facility is rated for biohazard-2 (BL2) containment. The equipment housed in the facility includes numerous computer-controlled sterilizable in-place and benchtop fermentors, and non-computer-controlled benchtop fermentors. These include two 100-liter, one 50-liter, and one 15-liter (working volume) sterilizable-in-place fermentors, and benchtop fermentors with working volumes of 1, 2, 5, and 10-liters. All fermentors have pH, temperature, agitation, and antifoam controllers, and almost all fermentors have dissolved oxygen controllers. Downstream processing equipment includes an Amicaon hollow-fiber filtration unit, SLM "French" pressure cell press, Cepa Z41 continuous centrifuge and swinging-bucket 4-liter centrifuge. Additional equipment includes an 8-shelf freeze-dryer which can be used for bulk drying, and a pure-culture production system (harvest and freeze drying in vacuum-sealed vials). Culture medium-steralization and 100-liter volume aseptic dispensing systems also are available.
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