Seed grant to study COVID-19

July 22, 2020

We are part of a team that has been awarded a small seed grant by the Office of the Vice President for Research to investigate translation mechanisms of SARS-CoV-2, the virus that causes COVID-19.  The project, "Analysis and Therapeutic Targeting of the SARS‐CoV‐2 Frameshift Element” is headed by Asst. Prof. Walter Moss (Principal Investigator, Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology), and also includes Prof. Cathy Miller (Veterinary Microbiology and Preventive Medicine Department).   The goal is to determine if the unusual translation (protein synthesis) mechanism called ribosomal frameshifting, which is used by the virus to express its replication proteins, may be a suitable target for antiviral thereapeutics.  The seed grant funds will be used to develop tools, assays and preliminary data necessary to obtain larger grants from external funding sources.